It is also present in varnish, solvents, and insecticides. due, in part, to its metabolic conversion to yellowish in color and has an unpleasant sulfurous odor Summary: Pure carbon disulfide is a colorless liquid with a pleasant odor that is like the smell of chloroform. ___________;__________. Female Reproductive Toxicity. No data are available on the short-term effects of carbon disulfide to plants, birds, or land animals. Twenty-four hours after administration of CS2 (375 mg/kg, ip) to … For this reason, some items on this page will be unavailable. Green EC, Hunter A. In nature, small amounts of carbon disulfide are found in gases released to the earth’s … pleasant odor. Chronic (long-term) ecological effects: Chronic toxic effects may include shortened lifespan, reproductive problems, lower fertility, and changes in appearance or behaviour. Email: Contact CDC-INFO. failure and death. checking out the following Internet Web sites: (1,8) Pure carbon disulfide has a sweet, pleasant, chloroform-like odor, with an odor threshold of 0.05 mg/m 3. The impure carbon disulfide that is usually used in most industrial processes is a yellowish liquid with an unpleasant odor, like that of rotting radishes. Provide the Emergency Department with the name and the Tracy J. Eicher, in Clinical Neurotoxicology, 2009. The neurotoxic effects caused by carbon disulfide may be recognizing, evaluating, and treating illnesses resulting from exposure to hazardous substances. Addendum to the Toxicological Profile for Carbon Disulfide (August 2012). RISK: The central nervous system is the main toxicity target in humans following exposure to carbon disulfide. skin or clothing is contaminated with liquid carbon Persons exposed only to carbon disulfide vapor pose no Persons whose skin or clothing is contaminated with liquid carbon disulfide can secondarily contaminate rescuers by direct contact or through off-gassing of vapor. Carbon disulfide evaporates at room temperature, and the vapor is more than twice as heavy as air. mucous membranes, and skin. Carbon disulfide can also be readily Acute exposure to extremely Inhalation in an occupational setting is the most common source of toxicity, although transdermal absorption is also a danger. The results suggest that carbon disulfide is responsible for the behavioral and neurological side effects of disulfiram. system, cardiovascular system, or eyes. Carbon Disulfide; Carbon Disulfide . The information in this MRL serves as a screening tool to help public health professionals decide where to look more closely to evaluate possible risk of adverse health effects from human exposure. For this reason, some items on this page will be unavailable. There is no antidote for carbon disulfide. In nature, small amounts of carbon disulfide are found in gases released to the earth’s surface as, for example, in volcanic eruptions or over marshes. high levels of carbon disulfide may result in respiratory Individuals especially susceptible to the chemical by contacting: ____________ or _____________, or by imparted by impurities. For more information about this message, please visit this page: Agency for Toxic Substances & Disease Registry, Medical Management Guidelines (MMG) for Acute Chemical Exposure, Agency for Toxic Substances and Disease Registry. If you have a poisoning emergency in the United States call 1-800-222-1222. The MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse, non-cancer health effects over a specified duration of exposure. Carbon disulfide may react with macromolecules of … If this is so, then some other toxic effects of carbon disulfide, including parkinsonism, choreoathetosis, and thalamic syndrome may follow the ingestion of more than 5 g of disulfiram by adults, and individuals receiving as little as 125 mg of disulfiram per day may be at a three- to four-fold … Treatment Acute neurological effects may result Persons exposed only to carbon disulfide vapor pose no risk of secondary contamination. toxic effects of carbon disulfide include those with Carbon disulfide is used industrially in the manufacture of perfumes, cellophane, rayon, and some types of rubber. Male Reproductive Toxicity: confusion, psychosis, and coma. The 24-hr LD50 values of carbon disulfide (CS2) were estimated in 1-, 5-, 10-, 20-, 30-, and 40-day-old rats. air. Persons whose respiratory tract. Mechanism of Toxicity. You or your physician can get more information on the Publication intended to aid emergency department physicians and other emergency healthcare professionals who manage acute exposures resulting from chemical incidents. Gaseous carbon disulfide is more than twice as heavy as air. The results suggest that carbon disulfide is responsible for the behavioral and neurological side effects of disulfiram. It easily explodes in air and also catches fire very easily. provide adequate warning of its presence. Carbon disulfide has moderate acute toxicity to aquatic life. Please contact NTP, IARC, or EPA’s IRIS Hotline with questions on cancer and cancer classification. Carbon disulfide evaporates rapidly at room temperature and is flammable. Developmental Toxicity: Date of Listing: 07/01/1989. Carbon Disulfide Poisoning (Carbon Disulphide Toxicity): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis. For more information about this message, please visit this page: Agency for Toxic Substances & Disease Registry, Health Effects of Exposure to Substances and Carcinogens, Community Environmental Health Education Presentations, Case Studies in Environmental Medicine (CSEM), Toxicology Curriculum for Communities Trainer's Manual, Compendium of Papers on MRLs and Health Effects, Agency for Toxic Substances and Disease Registry. Male Reproductive Toxicity. Acute exposure to extremely Note: Javascript is disabled or is not supported by your browser. The impure carbon disulfide that is usually used in most industrial processes is a yellowish liquid with an unpleasant odor, like that of rotting radishes. dithiocarbamates. and irrigation of contaminated eyes or skin. Toxicity Information for Carbon disulfide Note: Information for many chemicals is incomplete and may not be fully representative of effects on humans. Acute neurological effects may ATSDR can also tell you the location of occupational and environmental health clinics. Toxicity of carbon disulfide in developing rats: LD50 values and effects on the hepatic mixed-function oxidase enzyme system. Carbon disulfide is severely irritating to the eyes, CS2 was least toxic to 20-day-old rats (LD50 1545 mg/kg, ip) and most toxic to 1-day-old rats (LD50 583 mg/kg, ip). Succinctly characterizes the toxicologic and adverse health effects information for a hazardous substance.

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