Acute chest syndrome (ACS) is a group of symptoms that occur when sickled cells become clumped together in the lungs (Picture 1). It is defined as a new radiodensity on chest radiograph accompanied by fever and/or respiratory symptoms. Acute chest syndrome is a clinical syndrome which is defined as the combination of: (1) A new opacity on chest x-ray. The presenting symptoms and signs vary with age, fever and cough being more common in very young children and chest pain, shortness of breath, and hemoptysis being more prominent with advancing age. Acute chest syndrome is an important complication of sickle cell disease characterised by fever and/or respiratory symptoms and a new pulmonary infiltrate on chest X-Ray. acute chest syndrome: a syndrome occurring in association with sickle cell disease defined by a new infiltrate on chest radiograph; associated with one or more new symptoms: fever, cough, sputum production, dyspnea, or hypoxia. The acute chest syndrome is a vaso-occlusive crisis of the pulmonary vasculature commonly seen in people with sickle cell anemia.This condition commonly manifests with a new opacification of the lung(s) on a chest … Clinical features. ACS is characterized by fever, chest pain, difficulty breathing, hypoxia, and lung infiltrates. Acute chest syndrome has a multifactorial aetiology and an infective cause is common and this should be considered in treatment algorithms (1B). Acute chest syndrome. It is one of the most common causes of death in sickle cell anemia patients.. Clinical symptoms. ACS can be triggered by a lung infection like pneumonia.It may also happen before, during or after a pain episode. (2) Fever and/or respiratory symptoms (e.g., cough, dyspnea, or chest pain). It occurs most commonly in the 2-4-year-old age group and declines in incidence with age. Children with ACS usually complain of chest pain. Acute chest syndrome (ACS) episodes are characterized by fever, chest pain, and respiratory symptoms including productive cough, wheeze, and dyspnea. Acute chest syndrome is the second most common reason for hospitalization in SCD and is … This is an intentionally broad definition which doesn't exclude other diagnoses. Acute chest syndrome (ACS) is a frequent complication of sickle cell anemia.It can occur as an isolated event or develop during hospitalization for acute vaso-occlusive crisis (VOC). ACS requires prompt management to prevent clinical deterioration and death. Patients should be monitored for this complication throughout their hospital stay and all hospitals should have a treatment pathway for care. Acute chest syndrome is a term used to cover conditions characterized by fever and/or new respiratory symptoms such as chest pain, cough, hypoxia (low oxygen level) accompanied by the presence of a new pulmonary infiltrate on chest X-ray 1).Acute chest syndrome is a frequent cause of acute lung disease in children with sickle cell disease. Acute chest syndrome (ACS) is a leading cause of death for patients with sickle cell disease (SCD). They may also have a fever, cough or trouble breathing.
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